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DOI : 10.17693/yunus.89722 Viewed : 3229 - Downloaded : 1899 In this study, seasonal variations in biochemical composition and meat quality of Mediterrian Mussel in the Eastern Black Sea Region were investigated. Percentage of meat yield of Mediterrian Mussel was observed higher in summer and autumn than spring and winter. General average of the four seasons were determined as 24,00 %. Significant variation in the amounts of dry matter, crude ash, crude protein, crude fat and glycogen were occurred depending on seasons and stations. The general average values of all seasons were accounted as 18,95%, 1,70%, 12,04%, 1,82% and 3,38% respectively. Amount of crude protein increased seasonally (spring and summer) during the intensive feeding time. Lipid contents decreased in summer and autumn because of activity of mussel in the reproductive period. According to the results, it was thought to be benefit consumption of mussel having high nutritional value in terms of healthy diet. However, determination of the suitable collection or aquaculture areas nonaffected by the pollution sources would be appropriate. Keywords : Mediterrian Mussel, Biochemical composition, Seasons, Eastern Black Sea