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¹ Department of Pathology, College of Veterinary, University of Mosul, Mosul, Iraq DOI : 10.17693/yunusae.v2014i21954.235706 Viewed : 2222 - Downloaded : 1829 The aim of these study was to assess the effect of Sodium Chloride NaCl on blood picture as hemoglobin (Hb), packed cell volume (PCV) and lymphocyte count also the activity of both enzymes Alanine amino Transferase (ALT) and Creatine Phospho kinase (CPK) in Cyprinus carpio. NaCl was used at different concentration (0.5,1 and 1.5)mgL for 7 day .The concentration 1.5 mgL was toxic to the fish and cause death after 48 hour of exposure ,while in the fish that were exposure separately to both concentration (0.5 and 1)mgL for 7day there were no any significant differences in blood picture and activity of both enzyme ALT and CPK in these groups and control group .So the NaCl may be toxic in high concentration but safety if it was used in low concentration . Keywords :